The state of cell block variation and satisfaction in the era of molecular diagnostics and personalized medicine
Identifieur interne : 000C21 ( Main/Exploration ); précédent : 000C20; suivant : 000C22The state of cell block variation and satisfaction in the era of molecular diagnostics and personalized medicine
Auteurs : John P. Crapanzano [États-Unis] ; Jonas J. Heymann [États-Unis] ; Sara Monaco [États-Unis] ; Aziza Nassar [États-Unis] ; Anjali Saqi [États-Unis]Source :
- CytoJournal [ 0974-5963 ] ; 2014.
Abstract
In the recent past, algorithms and recommendations to standardize the morphological, immunohistochemical and molecular classification of lung cancers on cytology specimens have been proposed, and several organizations have recommended cell blocks (CBs) as the preferred modality for molecular testing. Based on the literature, there are several different techniques available for CB preparation-suggesting that there is no standard. The aim of this study was to conduct a survey of CB preparation techniques utilized in various practice settings and analyze current issues, if any.
A single E-mail with a link to an electronic survey was distributed to members of the American Society of Cytopathology and other pathologists. Questions pertaining to the participants’ practice setting and CBs-volume, method, quality and satisfaction-were included.
Of 95 respondents, 90/95 (94%) completed the survey and comprise the study group. Most participants practice in a community hospital/private practice (44%) or academic center (41%). On average, 14 CBs (range 0-50; median 10) are prepared by a laboratory daily. Over 10 methods are utilized: Plasma thrombin (33%), HistoGel (27%), Cellient automated cell block system (8%) and others (31%) respectively. Forty of 90 (44%) respondents are either unsatisfied or sometimes satisfied with their CB quality, with low-cellular yield being the leading cause of dissatisfaction. There was no statistical significance between the three most common CB preparation methods and satisfaction with quality.
Many are dissatisfied with their current method of CB preparation, and there is no consistent method to prepare CBs. In today's era of personalized medicine with an increasing array of molecular tests being applied to cytological specimens, there is a need for a standardized protocol for CB optimization to enhance cellularity.
Url:
DOI: 10.4103/1742-6413.129187
PubMed: 24799951
PubMed Central: 4007481
Affiliations:
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Crapanzano</name><affiliation wicri:level="2"><nlm:aff id="aff1">Address: Department of Pathology and Cell Biology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Address: Department of Pathology and Cell Biology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Heymann, Jonas J" sort="Heymann, Jonas J" uniqKey="Heymann J" first="Jonas J." last="Heymann">Jonas J. Heymann</name><affiliation wicri:level="2"><nlm:aff id="aff1">Address: Department of Pathology and Cell Biology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Address: Department of Pathology and Cell Biology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Monaco, Sara" sort="Monaco, Sara" uniqKey="Monaco S" first="Sara" last="Monaco">Sara Monaco</name><affiliation wicri:level="2"><nlm:aff id="aff2">University of Pittsburgh Medical Center, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Nassar, Aziza" sort="Nassar, Aziza" uniqKey="Nassar A" first="Aziza" last="Nassar">Aziza Nassar</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Saqi, Anjali" sort="Saqi, Anjali" uniqKey="Saqi A" first="Anjali" last="Saqi">Anjali Saqi</name><affiliation wicri:level="2"><nlm:aff id="aff1">Address: Department of Pathology and Cell Biology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Address: Department of Pathology and Cell Biology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">CytoJournal</title><idno type="ISSN">0974-5963</idno><idno type="eISSN">1742-6413</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>In the recent past, algorithms and recommendations to standardize the morphological, immunohistochemical and molecular classification of lung cancers on cytology specimens have been proposed, and several organizations have recommended cell blocks (CBs) as the preferred modality for molecular testing. Based on the literature, there are several different techniques available for CB preparation-suggesting that there is no standard. The aim of this study was to conduct a survey of CB preparation techniques utilized in various practice settings and analyze current issues, if any.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>A single E-mail with a link to an electronic survey was distributed to members of the American Society of Cytopathology and other pathologists. Questions pertaining to the participants’ practice setting and CBs-volume, method, quality and satisfaction-were included.</p></sec><sec id="st3"><title>Results:</title><p>Of 95 respondents, 90/95 (94%) completed the survey and comprise the study group. Most participants practice in a community hospital/private practice (44%) or academic center (41%). On average, 14 CBs (range 0-50; median 10) are prepared by a laboratory daily. Over 10 methods are utilized: Plasma thrombin (33%), HistoGel (27%), Cellient automated cell block system (8%) and others (31%) respectively. Forty of 90 (44%) respondents are either unsatisfied or sometimes satisfied with their CB quality, with low-cellular yield being the leading cause of dissatisfaction. There was no statistical significance between the three most common CB preparation methods and satisfaction with quality.</p></sec><sec id="st4"><title>Discussion:</title><p>Many are dissatisfied with their current method of CB preparation, and there is no consistent method to prepare CBs. In today's era of personalized medicine with an increasing array of molecular tests being applied to cytological specimens, there is a need for a standardized protocol for CB optimization to enhance cellularity.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Loukeris, K" uniqKey="Loukeris K">K Loukeris</name></author><author><name sortKey="Vazquez, Mf" uniqKey="Vazquez M">MF Vazquez</name></author><author><name sortKey="Sica, G" uniqKey="Sica G">G Sica</name></author><author><name sortKey="Wagner, P" uniqKey="Wagner P">P Wagner</name></author><author><name sortKey="Yankelevitz, Df" uniqKey="Yankelevitz D">DF Yankelevitz</name></author><author><name sortKey="Henschke, Ci" uniqKey="Henschke C">CI Henschke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yung, Rc" uniqKey="Yung R">RC Yung</name></author><author><name sortKey="Otell, S" uniqKey="Otell S">S Otell</name></author><author><name 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uniqKey="Kaneko C">C Kaneko</name></author><author><name sortKey="Kobayashi, Tk" uniqKey="Kobayashi T">TK Kobayashi</name></author><author><name sortKey="Hasegawa, K" uniqKey="Hasegawa K">K Hasegawa</name></author><author><name sortKey="Udagawa, Y" uniqKey="Udagawa Y">Y Udagawa</name></author><author><name sortKey="Iwai, M" uniqKey="Iwai M">M Iwai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zito, Fa" uniqKey="Zito F">FA Zito</name></author><author><name sortKey="Gadaleta, Cd" uniqKey="Gadaleta C">CD Gadaleta</name></author><author><name sortKey="Salvatore, C" uniqKey="Salvatore C">C Salvatore</name></author><author><name sortKey="Filotico, R" uniqKey="Filotico R">R Filotico</name></author><author><name sortKey="Labriola, A" uniqKey="Labriola A">A Labriola</name></author><author><name sortKey="Marzullo, A" uniqKey="Marzullo A">A Marzullo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakajima, T" uniqKey="Nakajima T">T Nakajima</name></author><author><name sortKey="Yasufuku, K" uniqKey="Yasufuku K">K Yasufuku</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li><li>Pennsylvanie</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Crapanzano, John P" sort="Crapanzano, John P" uniqKey="Crapanzano J" first="John P." last="Crapanzano">John P. Crapanzano</name></region><name sortKey="Heymann, Jonas J" sort="Heymann, Jonas J" uniqKey="Heymann J" first="Jonas J." last="Heymann">Jonas J. Heymann</name><name sortKey="Monaco, Sara" sort="Monaco, Sara" uniqKey="Monaco S" first="Sara" last="Monaco">Sara Monaco</name><name sortKey="Nassar, Aziza" sort="Nassar, Aziza" uniqKey="Nassar A" first="Aziza" last="Nassar">Aziza Nassar</name><name sortKey="Saqi, Anjali" sort="Saqi, Anjali" uniqKey="Saqi A" first="Anjali" last="Saqi">Anjali Saqi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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